The Library
HR EXECUTIVE

One decision-maker per team: Inside Pfizer’s cross-functional operating model

news_articleby Jill BarthMarch 17, 2026 3 min read
cross-functional teams organizational design decision-making authority performance management integration pfizer operating model accountability structures change management

Editorial summary. This is our text summary of an article published by hr-executive. Charts, figures, and the author’s full voice are at the original — read it there .

Editorial verdict

Credible practitioner account. The organizational design logic is internally consistent and the Workday integration detail adds unusual specificity — but this is a single-company narrative with no comparative data or outcome metrics to validate the model's effectiveness.

Executive summary

This article examines how Pfizer operationalized lessons from its COVID-19 vaccine development into a permanent cross-functional operating model. The central problem addressed is how to sustain the speed and decisiveness of crisis-mode operations within a large, historically bureaucratic organization. Sherry Cassano, Pfizer's chief talent officer, describes a framework called 'project-based ways of working,' anchored by three principles: a single accountable decision-maker per team (the 'pilot in command'), a maximum of one governance layer above the team ('air traffic control'), and fit-for-purpose team composition. Key evidence includes the model's scaling trajectory from 9 to 700 teams, and its embedding into Workday's performance management system, where the pilot in command — not the functional manager — assesses project-related performance. Two implementation challenges are identified: functional managers required more transition support than anticipated, and teams systematically underestimated the scope of their own authority. The article concludes that structural change requires both system-level reinforcement and deliberate psychological safety work to become culturally embedded.

case-studyRelevance: 8/10Global

Key insights

  • 1Pfizer's 'pilot in command' model assigns single-person accountability to cross-functional teams, explicitly displacing committee-based and co-lead structures.
  • 2Performance management system integration — specifically graying out functional manager fields for project goals in Workday — was identified as a critical mechanism for making authority structures visible and enforceable.
  • 3Functional managers experienced significant role disruption as their responsibilities shifted from decision-making to coaching, a transition the organization underestimated and had to address through dedicated support forums.

Practical takeaways

  • Embedding authority structures directly into performance management software (e.g., restricting field access by role) can operationalize organizational design decisions in ways that slide decks and policy documents cannot.
  • Scaling a new operating model requires parallel workstreams: one for team-level capability building and one for the managers whose roles are substantively changed by the new structure.

Source & Provenance

Verified
Publisher / Source

hr-executive

Author

Jill Barth

Publication Date

March 17, 2026

Article Type

Case Study

Geography

Global

Content Type
News Article
Original Source

Original source metadata is preserved. AI analysis is generated separately.

Like this? Get the Monday Decision Brief — free, every week.

No spam, unsubscribe anytime.

Rate this article

Want the full article? Read it at the original source — free, no paywall.

Read original article
All content belongs to original publishers. AI analysis is for research purposes only. View original source.